FERNANDES, M. F.; http://lattes.cnpq.br/6822726119450012; FERNANDES, Mayanna de Freitas.
Resumo:
This study focused on testing the null hypothesis that there is no difference
between the biocompatibility of orthodontic cement modified by diacetate of
chlorhexidine (DC) at different concentrations. Sixty Wistar rats were used
males, distributed in 5 groups (n=12), being: Group C (control, tube of
polyethylene), Group P (Conventional glass ionomer cement, Precedent) and
PD1, PD2 and PD3 groups (Precedent, modified with 1%, 2% and 3% DC,
respectively). The animals were sacrificed after 7, 15 and 30 days and the
tissues analyzed under optical microscopy for infiltration events
inflammation, edema, necrosis, granulation tissue, giant cells,
young fibroblasts and collagen fibers. The results were analyzed by the
Kruskal-Wallis and Dunn tests (p<0.05). In the initial period, intense infiltration
inflammation was demonstrated mainly in the PD1, PD2 and PD3 groups, with
statistically significant difference between the Control Group and PD3 (P=0.009)
at times of 7, 15 and 30 days. Multinucleated giant cells were shown
more present in the PD3 Group, with a statistical difference with the Control Group
in the time periods of 7 (P=0.021) and 15 days (P=0.042). The PD3 Group
demonstrated the smallest amounts of collagen fibers between the groups, with
statistical difference with the control group in the time period of 15 (P=0.049)
and 30 days (P=0.029). The null hypothesis was partially accepted. precedent
modified with 3% DC influenced more the inflammatory process, cells
giants and amount of collagen fibers than concentrations of 1% and 2%.