NERI, C. M. M.; http://lattes.cnpq.br/8156036314066320; NERI, Clarissa de Morais Martins.
Abstract:
For a long time plants are used by population in order to treat and cure diseases. In dentistry it
has encouraged the evaluation of different plant extracts for the oral biofilm control. Terpenes
are secondary metabolites that mediate important interactions between plants and the
environment. Many terpenes are widely used in agriculture, food and industries and as a
general antiseptic in medical practice. Studies have shown that terpenes have several
pharmacological properties including antifungal, antibacterial, anti-inflammatory, antioxidant
and anti-spasmodic. Therefore, the present study aims to evaluate the potential toxicity of
some of these terpenes, Betulinic Acid, Betulin and oleanolic acid, using in silico models.
When performing the methodological classification of this research, we realized that it is an
applied, quantitative and experimental study. All chemical information from the selected
terpenes were obtained in the site http://www.chemspider.com/. For the analysis of theoretical
toxicity it was submitted to the in silico study of ADMET parameters using the Osiris
Property Explorer program. For the analysis of obtained data in the research it was used the
software Microsoft Excel® 2010. On the results found in this study, the three analyzed
terpenes, as well as chlorhexidine, showed no mutagenic, tumorigenic and irritating
potentials, and also did not present damage to the reproductive system being classified on the
scale 1, absent significant damage. Demonstrating, in silico, the safety of these compounds,
however, clinical trials are crucial to prove these results. It can be concluded that, as well as
Chlorhexidine, these terpenes are being discovered to develop alternative therapies in
dentistry, and in silico tests are extremely important to check the quality of these new
compounds.