ROBERTO, B. M S.; ROBERTO, Berthiene Medeiros Salvador.
Abstract:
An atraumatic treatment for surgical wounds that restores tissue to its
condition of normality was what led over the years to the emergence of different
materials such as absorbable, non-absorbable, monofilament suture threads,
multifilaments, surgical cements and cyanoacrylate-based adhesives, the latter
has been extensively evaluated both in medicine and dentistry with results
promising. This study focused on histologically analyzing the
biocompatibility of cyanoacrylate-based adhesives: ethyl-cyanoacrylate (Tek
Bond) and n-butyl-2 + octyl-2-cyanoacrylate (GlubranTiss) in subcutaneous tissue of rats.
Thirty-six male Wistar rats were used, divided into 3 groups (n=12), as follows:
Group C (control, PVA Sponge), Group EC (Ethyl-cyanoacrylate) and Group NO (Nbutyl+
2-Octyl cyanoacrylate). The animals were sacrificed after 7, 15 and 30 days and the
tissues analyzed under optical microscopy for infiltration events
inflammatory, edema, necrosis, granulation tissue, giant cells, fibroblasts
youth and collagen fibers. The results were analyzed by the Kruskal-
Wallis and Dunn (P<0.05). Intense inflammatory infiltrate was demonstrated in the NO groups
and EC, with a significant difference between the Control Group and the NO and EC Groups in
time of 7 (P=0.012) and 30 days (P=0.008), and between the Control and NO Groups in the time
of 15 days (P=0.013). Giant cells were more expressive in the NO Group throughout
of the experiment, there was a statistical difference between the Control and NO Groups in
times of 15 (P=0.006) and 30 days (P=0.028). The amount of collagen fibers
increased throughout the experiment, there was a statistically significant difference
only between the Control and EC Groups at 30 days (P=0.033). you can
conclude that the adhesive N-butyl + 2-Octyl cyanoacrylate had a greater influence on the amount of multinucleated giant cells, and the Ethyl-cyanoacrylate showed a lower amount of collagen fibers in the time of 30 days.
