OLIVEIRA, C. C.; http://lattes.cnpq.br/8016496657062695; OLIVEIRA, Clédson Calixto de.
Resumo:
Given the need to explore the clinicopathological aspects of overdose by synthetic
anthelmintic, this dissertation presents in the prelude a systematic review with relevant
information about the cases of anthelmintic intoxication in goats and sheep., Then, through a
prospective study, it evaluated the clinical and laboratory parameters of the experimental
administration of the therapeutic dose and overdoses of 34% nitroxinil in healthy goats in
simulated intensive and semiintensive
regimens. The search of primary studies for the
systematic review was carried out in five electronic databases: Science Direct, PubMed,
Scopus, Web of Science and SciELO. The search terms used were: (Antihelmintic OR
Antiparasitic OR Vermifuge) AND (poisoning OR toxicity OR overdose OR intoxication)
AND (Goat OR Sheep). Twentyeight
articles were included for the elaboration of the
systematic review and they described cases of intoxication by twelve drugs, namely:
albendazole (2), closantel (14), disophenol (1), ivermectin (1), levamisole (2), moxidectin (1),
netobimin (1), nitroxynil (1), oxfendazole (2), parbendazole (2), tetramizole (1) and
Thiabendazole (1). The data obtained from this review reinforce the care that must be applied
to use these drugs safely in an attempt to avoid intoxication. In continuation of this
dissertation, a prospective randomized controlled clinical study with twelve goats distributed
in two experimental groups, GR (rest group) and GE (exercise group) was performed.
Therefore, doses ranging from 10 to 50 mg/kg of Nitroxinil 34% were administered
subcutaneously in a single dose. Clinical changes were observed in animals that received 3, 4
and 5 times the therapeutic dose (xDT). One death was recorded in the animal that received
5xDT from the GR with marked signs of apathy tachypnea, anorexia and recumbency.
Regarding the hematological parameters, a leukocytosis with neutrophilia associated with
lymphopenia was evident. As for the biochemical parameters, a possible picture of acute
renal azotemia associated with hypoglycemia, strong acidbase
imbalance and progressive
muscle degeneration proportional to the dose of nitroxinil was observed. Nitroxinil
demonstrated relevant potential to cause serious clinical, blood gas and hematobiochemical
changes when administered five times the therapeutic dose in healthy goats.