SANTOS, M. E. F.; http://lattes.cnpq.br/3144101496409200; SANTOS, Maria Eduarda Fernandes dos.
Abstract:
Dyslipidemia is characterized by metabolic alterations in the lipid profile, which leads to an
increase in serum levels of total cholesterol, triglycerides, low-density lipoprotein (LDL), in
addition to a decrease in high-density lipoprotein (HDL). These changes are associated with an
increased risk for coronary heart disease. One of the treatments includes changing eating habits,
excluding sources of saturated and trans fat, in addition to including foods that can contribute
to improving this pathology. Foods considered to have functional property claims can play an
important role in these cases, acting in the control and improvement of this pathology. Garlic
is considered a functional food due to the presence of compounds that, according to the
evidence, play beneficial activities for the prevention/control of different pathologies. The
present work aims to analyze the literature and identify, through a literature review, the
functional properties of Garlic in the control of dyslipidemia. The articles were selected
between February and March 2022, through an automatic literature search, through databases
such as: Google Scholar, Scientific Electronic Library Online (Scielo), PubMED, Elsevier,
Virtual Health Library (BVS), using the search engines: Alho, Allium Sativum L and
dyslipidemia, in Portuguese, English and Spanish with a date of the last 5 years (2018-2022).
Sixteen works were selected, 12 with rodents and 4 with humans. Studies with dyslipidemic
animals, despite the different forms of administration and amounts, showed improvement in
almost all evaluated markers, the same was contemplated in human studies, with the exception
of one study that did not demonstrate significant improvement with supplementation. The
authors attributed the beneficial effects in the control of dyslipidemia to the organosulfur
compounds present in garlic, mainly allicin that acts in the synthesis of cholesterol. Thus, garlic
demonstrated the presence of functional properties in the control of dyslipidemia in almost all
studies, however, more trials in humans should be carried out, standardizing an administration
format and quantity.