SARAIVA, E. G.; http://lattes.cnpq.br/2023639282438239; SARAIVA, Elyadna Gadelha.
Resumen:
A series of pharmacological treatments are used to minimize bone disintegration caused
by osteoporosis, however, some treatment alternatives are responsible for producing an adverse
reaction consisting of tissue necrosis: osteonecrosis of the jaws. Thus, the objective of the
research was to investigate the bone repair process in wistar rats with osteoporosis induced by
dexamethasone treated with vitamin D and sodium alendronate, taking into account the present
macroscopic changes that may show osteonecrosis of the jaws. The research was carried out at
the Experimental Nutrition Laboratory of the Federal University of Campina Grande-CES,
according to the parameters established by the ethics committee. 24 wistar rats were used and
divided into four distinct groups representing each form of evaluation: the GA group composed
of 06 animals treated with sodium Alendronate; the GAD group composed of 06 animals
treated with vitamin D and sodium alendronate; the GO group that did not receive treatment for
osteoporosis, being only subjected to osteoporosis induction and making up the control group
with osteoporosis; and the CG group, which only received distilled water by oral gavage,
making up the total control group. There was induction of osteoporosis through the
administration of dexamethasone over a period of five weeks in the 18 animals of these first
three groups. After the induction, 12 animals were submitted to the isolated treatment of
alendronate sodium, and the association with vitamin D in the period of six weeks. Macroscopic
and radiological evaluations were performed. The results showed that the combination of
treatments group had the highest prevalence in the variable necrosis (83.3%), showing signs of
the last stage of the condition in the period of 45 days. However, for most specific signs, the
group treated with vitamin D association showed a lower prevalence of sequelae. Thus, it is
concluded that the osteorestorative action that Alendronate sodium presents does not overcome
the necrotic action that follows, its damage, however, being attenuated by the concomitant use
with vitamin D.