O uso dos inositóis no tratamento da síndrome dos ovários policísticos: revisão integrativa.

Abstract

Polycystic Polycystic ovary syndrome is a metabolic endocrinopathy that affects a considerable number of women of reproductive age. Presenting risk for the development of other complications including insulin resistance, diabetes mellitus, metabolic syndrome, and increased risk for endometrial cancer. Non-pharmacological treatment includes changes in lifestyle, which include food, diet and use of food supplements. The use of inositols has been an excellent ally in nutritional therapy for PCOS, especially in improving insulin resistance. Therefore, the present work aims to consolidate information on scientific evidence of the use of inositols in the treatment of polycystic ovary syndrome. An integrative review was carried out in the Google Scholar databases, PubMed, Scielo, Science Direct and the Virtual Health Library (VHL), with the combined use of the descriptors “Polycystic Ovary Syndrome” and “Inositol” in English only, selecting articles from the last 5 years (2018 to 2022). After applying the filters in the databases, 3994 articles were obtained, after performing the title and abstract analysis, it resulted in 17 articles that were analyzed in full text. At the end of the application of all inclusion and exclusion criteria, it resulted in 14 articles that were included in this review, 12 performed in humans and 2 in animals. The analyzed studies demonstrate that the use of inositols has favorable benefits in improving insulin resistance, compared to metformin. Metformin, despite promoting an excellent improvement in insulin resistance, reduces the total antioxidant capacity. And treatment with inositol alone or associated with metformin showed a possible antioxidant effect of inositol. The consumption of a diet rich in inositol or supplementation with isositol showed relevance in reducing insulin resistance, promoted improvement in the LH/FSH ratio and improvement in the menstrual cycle. However, the results are controversial regarding the improvement in ovulation and pregnancy rates. Regarding the proportions that best treat the effects of PCOS, the analyzed studies demonstrated that the 40:1 ratio of MI/INN has more positive effects. When using higher proportions of DCI in relation to MI, it seems to be unfavorable in the ovarian morphology. Therefore.