SILVA, S. P. B.; http://lattes.cnpq.br/0844850367110180; SILVA, Socorro da Piedade Berto da.
Résumé:
Polycystic Polycystic ovary syndrome is a metabolic endocrinopathy that affects a considerable
number of women of reproductive age. Presenting risk for the development of other
complications including insulin resistance, diabetes mellitus, metabolic syndrome, and
increased risk for endometrial cancer. Non-pharmacological treatment includes changes in
lifestyle, which include food, diet and use of food supplements. The use of inositols has been
an excellent ally in nutritional therapy for PCOS, especially in improving insulin resistance.
Therefore, the present work aims to consolidate information on scientific evidence of the use
of inositols in the treatment of polycystic ovary syndrome. An integrative review was carried
out in the Google Scholar databases, PubMed, Scielo, Science Direct and the Virtual Health
Library (VHL), with the combined use of the descriptors “Polycystic Ovary Syndrome” and
“Inositol” in English only, selecting articles from the last 5 years (2018 to 2022). After applying
the filters in the databases, 3994 articles were obtained, after performing the title and abstract
analysis, it resulted in 17 articles that were analyzed in full text. At the end of the application
of all inclusion and exclusion criteria, it resulted in 14 articles that were included in this review,
12 performed in humans and 2 in animals. The analyzed studies demonstrate that the use of
inositols has favorable benefits in improving insulin resistance, compared to metformin.
Metformin, despite promoting an excellent improvement in insulin resistance, reduces the total
antioxidant capacity. And treatment with inositol alone or associated with metformin showed a
possible antioxidant effect of inositol. The consumption of a diet rich in inositol or
supplementation with isositol showed relevance in reducing insulin resistance, promoted
improvement in the LH/FSH ratio and improvement in the menstrual cycle. However, the
results are controversial regarding the improvement in ovulation and pregnancy rates.
Regarding the proportions that best treat the effects of PCOS, the analyzed studies demonstrated
that the 40:1 ratio of MI/INN has more positive effects. When using higher proportions of DCI
in relation to MI, it seems to be unfavorable in the ovarian morphology. Therefore.