Perfil clínico-epidemiológico dos pacientes atendidos no Hospital Universitário Alcides Carneiro com deficiência múltipla de hormônios hipofisários.

Abstract

The pituitary hormone deficiency is characterized by a partial or complete loss of one or more pituitary hormones of the adenohypophysis and/or neurohypophysis. When is diagnosed dysfunction of two or more pituitary hormones, has the so-called multiple pituitary hormone deficiency (MPHD). Its etiology includes hereditary and acquires causes. Clinial manifestations of DMHH depend on the extent of hormone deficiency and can be nonspecific or specific, related of the function of the impaired hormone in question. This study aims to evaluate, during the period from September 2011 to August 2012, the central epidemiological chacteristics and clinical presentation of patients with Multiple Disabilities Ptuitary assisted by the service of Endocrinology and Metalbolism, Hospital Universitário Alcides Carneiro. Material and Methods: assessment and evaluation form filling of patients diagnosed with DMHH and followed the abovementioned service. Results: GH deficiency was more prevalent among all pituitary hormones, being observed in 100% of patients. The initial complaint was also more commonly reported related to this hormone, since short stature is one of the early symptoms that bothers the patient. As for laboratory findings, hormonal deficiencies have been proven in the following proportions: GH in all patients, LH and FSH in 12 (70.58%), TSH and ACTH in 8 (47.05%). The correspondences between deficiency and laboratory-related clinical manifestations were as follows: 94.11% for GH; for LH and FSH 91.66%; 50% for TSH, ACTH 25%. Conclusion: The pattern followed the most frequent deficiencies of literature, being initially symptoms of GH deficit followed by symptoms of gonadotropin deficit.