BARBOSA, A. V.; FREIRE, J. C.; http://lattes.cnpq.br/4183189006012672; http://lattes.cnpq.br/7539603515298557; BARBOSA, Amanda Vieira.; FREIRE, Juliana Carvalho.
Resumen:
Migraine is a form of common, highly disabling primary headache associated with a
high socioeconomic burden and high prevalence. The approach and therapy of this
condition ranges from the removal of triggers, use of preventive medications and other
therapies. The objective of this study was to evaluate the efficacy of the use of tramadol
50 mg + metoclopramide 5 mg, compared to placebo, for the treatment of acute attacks
of migraine. Methods: A randomized, controlled, double-blind clinical trial was
conducted in patients attending the Neurology outpatient clinic of the Alcides Carneiro
University Hospital located in Campina Grande, Brazil, evaluating the clinical and
socioeconomic profile and comparing the efficacy of the combination of tramadol 50mg
and metoclopramide 5mg, through Visual Analogue Scale, frequency and duration of
migraine and need for rescue medication. The data were collect before the intervention
and 30 days after the intervention, by telephone. Results: A total of 66 people
participated in the metoclopramide study compared to placebo (84.4% vs 88.2%), with
a diagnosis of migraine without aura (56.3% vs. 64.7%). After the 30 days, only 43
participants gave a return of the medication, between the groups it was evaluated
reduction reduction of EVA> 50% before and after the episode of migraine as primary
outcome and there was no significant difference between the group using tramadol
with metoclopramide and placebo (p = 0.11). The main side effect was nausea and /
or vomiting (40.9% vs 15%, p = 0.06), without distinction between groups.
Conclusions: The use of the combination of metoclopramide and tramadol (50mg /
5mg) was not superior to placebo as a treatment for acute attacks of migraine.
