MEDEIROS, D. A.; MEDEIROS, K. K. R. V.; http://lattes.cnpq.br/1258724886250268; http://lattes.cnpq.br/6762872210507052; MEDEIROS, Diogo Agripino de.; MEDEIROS, Kiara Kalline Rodrigues Virgulino de.
Resumo:
Insulin resistance (IR) is a condition in which the normal amounts of
insulin produced by the body are inadequate to provide a satisfactory response of
insulin action in adipocytes, muscle tissues and liver. Non-alcoholic fatty liver disease
(NAFLD) is the hepatic manifestation of IR. Objectives: to evaluate IR and its
association with NAFLD and coronary artery disease (CAD), and to describe
epidemiological, clinical and laboratory characteristics of patients with IR.
Methodology: a statistical analysis of the database derived from the study of
patients undergoing coronary angiography (CAG) in order to observe the frequency
of NAFLD in patients with coronary artery disease, according to pre-established
criteria, versus patients with normal CAG, between February 2009 and January 2011
in the city of Campina Grande (PB). All patients included in this study, after informed
consent, were assessed by questionnaire, clinical examination, laboratory tests and
ultrasound. Results: HOMA-IR ≥ 3.0 was present in 27.9 % (68 ) of the patients, this
condition was associated with a significantly higher average levels of blood glucose
and triglycerides, an association of CAD and NAFLD, (metabolic syndrome) MS and
type 2 diabetes mellitus (DM2) (p < 0 , 0001), overweight/obesity (p = 0.001) and
NAFLD alone (p = 0.015). Patients with RI and an association of CAD and NAFLD
has 6.18 times more likely to have hypertension (p = 0.016). Conclusion: patients
with insulin resistance had a significant relationship with increased blood glucose
levels, overweight and obesity, DM2, SM, hypertriglyceridemia, isolated NAFLD and
the presence of CAD and NAFLD association. In insulin-resistant patients who had
CAD and NAFLD association, (hypertension) HAS was the only significant risk factor
related to this association.