GOMES, L. R.; PEIXOTO, R. M.; http://lattes.cnpq.br/3833998443347589; http://lattes.cnpq.br/9606898459814795; GOMES, Lívia Rios.; PEIXOTO, Rodrigo Mendes.
Resumo:
The relationships between chronic arthropathy post-infection by
chikungunya and Rheumatoid arthritis: systematic review. Introduction:
Arboviruses are viral infections caused by arboviruses, transmitted to humans
through the bite of arthropods, and are the cause of diseases that have been a
cause of great concern for public health around the world. Among such
arboviruses is chikungunya. This is an acute systemic viral disease, caused by the
chikungunya virus, and transmitted by the vectors of the genus Aedes aegypti and
Aedes albopictus. It is characterized by high fever, rash, myalgia and severe pain
in the joints, affecting mainly the extremities. In certain patients, joint pain or
edema may persist for months or even years after the initial infection,
characterizing the chronic phase of the disease. Clinical manifestations in acute
and chronic infection may resemble some autoimmune diseases such as
rheumatoid arthritis, seronegative arthritis, and systemic lupus erythematosus.
Rheumatoid arthritis is a chronic autoimmune disease associated with
inflammation of the synovial membrane and leading to erosive joint processes.
Objective: To identify in the literature, through a systematic review, the possible
relationships described between chronic arthropathy caused by chikungunya and
rheumatoid arthritis. Methodology: Secondary analysis of data obtained from the
systematized search of articles in the LILACS, MEDLINE, PubMed and SciELO
databases between the period from 2015 to 2018. Results: Chronic arthropathy
was developed in 75.8% of the patients affected by chikungunya. Symmetrical
polyarthritis was found in 75% of cases. The main joints were those of the hands,
feet, ankles, knees, wrists, proximal interphalangeal and metacarpophalangeal
joints. Morning stiffness was observed in 71% of the patients and in 66% there
was significant absenteeism of the work functions. Conclusion: Rheumatoid
arthritis and chikungunya have a very similar clinic, sharing several
pathophysiological aspects, besides possible laboratory and imaging findings. It is
important to carry out the differential diagnosis between the two pathologies, which
can often be considered a challenge.