Estudo epidemiológico e clínico-laboratorial do uso de fenobarbital como anticonvulsivante entre pacientes do Hospital Universitário Alcides Carneiro (HUAC).

Abstract

This study characterized the profile of patients treated at the Alcides Carneiro University Hospital (HUAC), users oh phenobarbital in order to support actions of therapeutic drug monitoring. One hundred and sixteen patients were interviewed in 2 phases using standardized questionnaire and medical recorders analysis, aiming to perform a profile of users. Eleven patients were blood collected to monitoring drug. The patients were, mainly, children, female, first crisis at childhood and using the phenobarbital as monotherapy. The main anticonvulsivant drug combination was carbamazepine. The patients under monotherapy have more chance of success in controlling seizures and it seems to be a protective factor for adverse effects. The eleven blood collecting were analised by liquid chromatography. All seem to be under the therapeutic range.