SILVA, A. C. C.; PONTES FILHO, P. S. V.; http://lattes.cnpq.br/0659614909845916; SILVA, Ana Carolina Cândida da.; PONTES FILHO, Paulo Sérgio Viana.
Abstract:
Pregnancy is a period full of important adaptations on the maternal organism. The
changes on the nutritional needs and on the hormonal levels, intrinsic to the
gestational process, are immensely necessary to fetal growth and development.
Vitamin D deficiency, understood as a result of this increased maternal metabolic
rate – if unattended – can cause deep and worrisome alterations on prenatal,
perinatal and postnatal periods. Despite this, vitamin D supplementation during
pregnancy is not a common practice on Brazil. Therefore, on this Systematic Review,
we discuss the metabolism of vitamin D and its implications on pregnancy, the effects
of vitamin D deficiency on mothers and their offspring and we review recommended
the therapeutic range of an eventual supplementation of this vitamin. Our results
show that there are strong indications allowing the affirmation of an ideal therapeutic
range, on vitamin D supplementation during pregnancy, comprehending the interval
that goes from 1120 to 4460 daily international units. Also, our results show that the
most common starting period for this intervention was the second gestational
trimester. This way, we conclude that, although this therapeutic range is secure and
well established on the studies we revised, defining if the exact ideal dose is closer to
the lower established value (1120UI/day) or closer to the higher value established
(4460UI/day) is a point that requires further deepening. Besides that, despite the vast
majority of the studies revised having started their supplementations on the second
gestational trimester, this data might correspond to causality, as defining this aspect
of vitamin D supplementation was not a specific objective on any of the revised
articles.