NOGUEIRA JUNIOR, Francisco Assis.; PESSOA, Julyanna Damasceno.; ARAÚJO, Shirley Valesca Cavalcante.; SILVA, Osvaldo Soares da.; ALSINA, Odelsia Leonor Sánchez de.
Abstract:
The break-stone (Phyllantus Niruni l.) is an herb widely used by traditional medicine with established
pharmacological activity. The active principia in the extract are chemical compounds like steroids, alkaloids
and phenolic compounds, such as tannins and flavonoids, among others. In this work the in vitro dissolution
of tannins from granules of break-stone, coated in a conventional spouted bed by a film of gastro resistant
polymer, Eudragit base was studied. Gastro-resistant coating is a technique used in the preparation of
pharmaceutical forms in order to resist gastric juice action, but quickly disintegrate and absorb in intestinal
juice. The primary goal of this work was to assess the effect of process variables: polymer suspension flow
rate and air temperature, on the efficiency of the dissolution. The in vitro dissolution tests were conducted in
two stages: acidic and alkaline, representing gastric and enteric media respectively. In all the studied
conditions a partial gastro-resistance of the coating film was observed because some phenols were
dissolved during the acid stage. The best operating conditions for the process of coating in spouted bed
were identified in order to obtain gastro-resistant liberation of the pharmaceutical active components in the
granules.
