LIMA, F. H. C.; http://lattes.cnpq.br/2310977612154286; LIMA, Fabiany Hellen Castro de.
Resumo:
Mucormycosis is an infection caused by fungi of the order Mucorales, first described
by Paultauf in 1885. It is a disease that can have a fatal evolution, especially in
patients with a deficient immune system. Faced with the increase in resistance to the
antifungal agents used, as well as the limitation of therapeutic options, this study
aimed to identify which essential oils have the best antifungal activity Rhizopus. For
this purpose, a narrative review of the literature was carried out in scientific
databases: Pubmed, ScienceDirect, Medical Literature analysis and Retrieval Sistem
Online (MEDLINE,) SciELO, LILACS, CAPES Periodical Portal, Google Scholar and
the Virtual Health Library (VHL), using the descriptors Rhizopus, antifungal essential
oils and therapeutic use, using the combination with the Boolean AND operator and
refining the articles between the years 2010 and 2023. Using the inclusion and
exclusion criteria, 45 articles were selected. The essential oils with the highest
anti-Rhizopus activity were from the species: Thymus vulgaris; Cymbopogon citratus;
Rosmarinus officinalis, Citrus paradiseIt is Cinnamomum verum.The first two showed
proven inhibitory action and the remaining mechanism of action performed by them
was not identified. The tests were performed in vitro through microdilution,
macrodilution, micro atmosphere and in vivo with direct application on the target to
be evaluated as in the study of toxicity of the essential oil of Thymus schimperin
Wistar albino rats. It is concluded that the use of essential oils as a base or formula
enrichment can contribute to the development of new drugs. It turns out that the
studies in vitro may help in the continuation of the investigation of essential oils with
antifungal potential against strains of Rhizopus spp. for therapeutic purposes.