HOLANDA, M. D. C.; http://lattes.cnpq.br/7209849516381665; HOLANDA, Maria Danyelle Candeia de
Abstract:
Non-neoplastic proliferative processes (NNPPs) are inflammatory lesions that
frequently occur in oral cavity, caused by chronic and lasting stimuli. Among these, the
followingstand out: pyogenic granuloma (PG), peripheral ossifying fibroma (POF) and
peripheral giant cell lesions (PGCL). The present work sought to analyze the
sociodemographic, clinical, and histopathological characteristics of NNPPs. 57 cases
of PG (n = 20), POF (n = 20) and PGGCL (n = 17) were evaluated. Clinical forms
requesting histopathological analysis were evaluated to obtain sociodemographic data
such as: age, sex, race, occupation, and marital status. The same forms provided the
clinical data: appearance of the lesion, anatomical location, symptoms, type of
implantation, growth, type of growth, color, consistency, size, type of biopsy and
diagnostic hypothesis. For the morphological (histopathological) study, in the 5μm
histological sections arranged on glass slides and stained in Hematoxylin-Eosin (HE)
were evaluated: ulceration, bacterial colonization, inflammatory infiltrate, degree of
cellularization, characterization of the hard tissue and vascularization of the lesion.
NNPPs were more prevalent in females, from the third to the sixth decade of life. PG
and POF were more frequently found in the superior alveolar ridge, and GCPL was
more frequent in the inferior alveolar ridge. The three groups most exhibited a nodular
appearance, pink color, fibrous consistency, sessile implantation, exophytic and slow
growth, absent symptoms, and varied sizes. Among the morphological findings, in
general, the presence of ulceration in the lesions was commonly observed, being
present in 65%, 80% and 94.1% of the GP, FOP, LPCG respectively, and little bacterial
colonization. The degree of inflammation and cellularization were more pronounced in
GPs and LPCGs. As for the presence of hard tissue, it was present in the FOP and
LPCG, with no statistically significant differences in terms of intensity or
characterization, p=0.379 and p=0.539. The PG showed a tendency towards greater
vascularization among the lesions studied, but no difference was statistically significant
between the groups p=0.056. PPNNs are clinically very similar lesions that can be
prevented as long as the causal physical factors are eliminated, the patient is instructed
in preventive oral hygiene habits and the lesions are treated correctly.