SOUZA, Felipe Ravelly Alves de.; MUNIZ, Catarina Buson de Oliveira.; LIMA, Caio de Azevedo.; BORGES, Elder Miguel Esperidião Silva.; CAVALCANTE, Laedson Enéas.; AMORIM, Laura Araujo da Silva.; QUEIROZ, Jean César Farias de.
Abstract:
The emergence of increasingly drug resistant bacteria leads to the
constant prospection and production of more effective, broad spectrum drugs, low
toxicity and high specificity. The objective of the work in question was to evaluate the
production of antibiotics from the fermentation process in semisolid medium, using
filamentous fungi found in the Caatinga Biome, a microregion of Cariri - Paraíba. The
fungus used in the experiment belongs to the genus Aspergillus, named CDSA71,
obtained from the fungal collection of the Microbiology Laboratory of CDSA - UFCG,
Sumé. The microorganism was inoculated in oat medium and after its growth the
extraction of its metabolites was carried out by means of solvents. Then the metabolites
were tested by means of the antibiogram to check the antimicrobial activity. The fungi
were evaluated for their potential to produce antimicrobial compounds against Gram
negative (Escherichia coli) and Gram positive (Staphylococcus aureus) bacteria. The
antibiotic presented inhibitory halo of 2.42 cm and 2.25 cm in Escherichia coli and
Staphylococcus aureus, respectively. After the antibiogram, it was verified that the
metabolites produced by the fungus CDSA71 showed inhibition of the bacterial growth
against the strains used.
