Fármacos hepatotóxicos e hepatoprotetores: uma revisão de literatura.

Abstract

Despite the beneficial effects with prophylactic and curative purposes that drugs offer, they can cause harmful reactions to individuals, due to the reactivity of their metabolites, modifying their therapeutic effect. Hepatoprotective drugs are responsible for preventing and mitigating damage against toxic agents. The objective of the study was review and describe hepatotoxic and hepatoprotective drugs, and their respective mechanisms of action. This is an integrative review of the literature, the research was carried out on databases electronic data, using articles published in the last 5 years as inclusion criteria and recognized scientific rigor. The main pharmacological classes responsible for causing hepatotoxicity were: non-steroidal anti-inflammatory drugs, antimicrobials, anticonvulsants and antineoplastics, through direct and idiosyncratic mechanisms. Herbal medicines and vitamins, were considered the best safe and effective therapeutic option when the objective was the protection of liver cells. It can be concluded that there is a lack of scientific literature complete information on hepatotoxic and hepatoprotective drugs.