Efeitos da suplementação da nata caprina sobre a memória de ratos idosos.

Abstract

Aging is associated with cognitive decline and the consumption of essential fatty acids (FAs) can modulate this function. Dietary lipids can make up brain tissue and promote the fluidity of neuronal membranes, in addition to regulating neurotrophins responsible for inducing neuronal survival, development and function. Several scientific evidences have reported the positive effect of fatty acids on rodent memory. However, the effects of caprine cream consumption on the nervous system of aged rats they are not completely enlightened. Our objective was to investigate the impact of goat cream supplementation on memory parameters in elderly wistar rats. Two groups were formed: control (CG) - treated with distilled water and goat cream (C) - treated with 2,000 mg of goat cream / kg animal weight. For the concreteness of the study, the Open Field Habituation Test and Object Recognition Test (ORT) were performed from 545 days of age. Results were statistically analyzed and the result was considered significant when p <0.05. The Open Field Habituation test showed that rats supplemented with goat cream reduced ambulation activity on the second exposure to the apparatus, inferring memory consolidation (p <0.05). The animals from the NC group also showed positive results regarding the exploration rate in the object recognition test (ORT), where the animals supplemented with goat cream explored the new object longer when compared to the CG (p <0.05). Supplementation with goat cream seems to be efficient for the memory of aged rats, but other results need to be explored in order to identify the mechanisms that involve the action of GA with the improvement of cognitive performance.