Potencial antifúngico de óleos essenciais contra Candida auris: uma revisão integrativa.

Abstract

Candida auris has emerged as a pathogen of global concern since its first description and subsequent replicability across the world. Resistant to antifungal drugs and disinfection measures, the fungus has the potential to colonize abiotic surfaces and human skin, which allows it to grow through adherent communities, biofilms. Therefore, the objective was to evaluate the antifungal profile of essential oils in combating the resistant pathogen C. auris, through an integrative review of the literature. To this end, five databases were used to search for articles, namely Pubmed, Virtual Health Library (BVS), Google Scholar, SciELO and ScienceDirect, so that it was possible to obtain 1445 works. Only six studies remained in the analysis after applying the inclusion and exclusion criteria. In this way, the essential oils showed potential antifungal activity, proven through the following tests: determination of the minimum inhibitory concentration (MIC), determination of the minimum fungicidal concentration (CFM), association study of more than one compound using the checkerboard technique and investigation of antibiofilm activity. The oils that presented the best antifungal profiles, demonstrated from the tests, were Cinnamomun zeylanicum, Coriandrum sativum, Cinnamomum cassia, Lippia sidoides, Melaleuca alternifolia, Thymus vulgaris and Thymus zygis, pointing to the potential of volatile compounds in therapeutic applicability.