FURTADO, G. T. S.; http://lattes.cnpq.br/5547091699579497; FURTADO, Glória Tamiris Farias da Silva.
Résumé:
The cancer is growing in public health statistics, and the melanoma is one of the
most lethal types. Research has focused on substances that are less toxic and
can be released in a controlled way through the developoment of
pharmaceutical systems. To develop pharmaceutical systems are used polymer
materials, which will be responsible for the drug release control in situ. Chitosan
has been studied for having properties such as antimicrobial, analgesic, may be
chemically modified, easy and inexpensive. The aim of this study was to
develop and evaluate chitosan membranes for curcumin controlled release
systems for treating melanoma. Samples were prepared by solvent casting,
using a solution of acetic acid (1% v/v) to obtain a chitosan solution at 2% (w/v).
The membranes of chitosan/curcumin was obtained from the dissolution of
curcumin in ethanol (1.2 mg / ml) pouring the solution of chitosan, chitosan
membranes with and without curcumin were characterized by FTIR, XRD, SEM,
TG, DSC, SD, enzymatic degradation, cytotoxicity (MCF-7), and also performed
as the development and validation of the analytical method, and determination
of curcumin in membrane developed. From the characterizations became
evident that the processing method used in obtaining the chitosan
membrane/curcumin is appropriate, considering there was no degradation of
curcumin. The membranes of chitosan/curcumin showed lower swelling ratio
and degradation, and increased stability as compared to the chitosan
membranes. For the cytotoxicity assay the membranes of chitosan/curcumin
showed potential for the treatment of cancer. The developed analytical method
is accordint to the ANVISA resolution No. RE 899/2003. Therefore, the method
was suitable for identification and quantification of curcumin in chitosan/curcumin membranes. Based on these results, the system developed has potential for applications in controlled release of drugs.