Desenvolvimento farmacotécnico e caracterização de gel á base de Amburana cearensis.

Abstract

Amburana cearensis, known as cumaru, is a species belonging to the Fabaceae family, popularly used in the treatment of respiratory diseases. Studies show the presence of

phenolic compounds, alkaloids and coumarin in the bark of this plant, reporting anti-inflammatory activity. inflammatory, antioxidant, among others. Based on ethnopharmacological use, the objective of this

work was to develop a gel formulation containing glycolic extract of Amburana cearensis to relieve nasal congestion. To obtain the 20% glycolic extract, collected cumaru peels in the rural area of ​​the municipality of Coronel Ezequiel – RN. After filtration, the extract was analyzed for dry residue, pH, density and characterization phytochemistry. Subsequently, the extract was incorporated into a base gel and analyzed for organoleptic characteristics, spreadability and centrifugation test. The glycolic extract of cumaru peels presented the following characteristics: dry residue 0.50% ± 0.15 of extractives; pH 7.10 ± 0.11; density 1.0231 ± 0.025; and the phytochemical evaluation showed the presence of phenolic compounds, tannins and alkaloids. The gel produced presented the following composition: hydroxyethylcellulose, glycerin, propylene glycol, methylparaben, trietholamine, EDTA, glycolic extract of Amburana cearensis and distilled water. Regarding gel analysis, a characteristic odor of coumarin and a slightly yellowish color were observed; the gel presented adequate spreadability for uniform application without running during administration of the product. In the centrifugation test, it was observed that the sample was stable without any type of alteration, coalescence, phase changes, color or odor were not observed. It is concluded that the phytochemical profile of the cumaru bark obtained in this study is similar to those found in the literature related to this part of Amburana cearensis, pointing out its therapeutic potential. The gel demonstrated physicochemical characteristics suitable for use intended. However, stability studies are needed to evaluate the useful life of the product and pre-clinical and clinical trials to evaluate the safety and therapeutic efficacy of this gel, ensuring its applicability and potential benefits.