LOPES, D. L. E. G. Q.; http://lattes.cnpq.br/7630399765063530; GUEDES, Dayse de Lourdes Madruga Espínola.
Resumo:
This research aims to characterize chitosan films, sublingual application, for use in
controlled release of formoterol fumarate systems., Looking for a new alternative
for the emergency treatment of asthma attacks. We know that asthma is a disease
of high incidence in Brazil and in the world, because we have about 300milhões of
people with the disease worldwide and 20 million Brazilians .It is one hereditary
disease, chronic that has no cure and that often presents as a medical emergency,
because the crisis of the disease the relief should be immediate in order to prevent
the death of the patient. Today only is used inhalation as preferred for
administration of bronchodilators, since this route has faster action .In entando, we
are faced with the difficult technique for using inhalers that deliver the medicine
which often makes it impossible to use especially in children, the elderly and very
debilidados patients. Buy this difficulty, we proposed in our work to seek a new
route for the use of bronchodilators, which had the same effectiveness of inhaled,
eliminating the difficult technique of using drugs .For this, choose the sublingual
route of fast action and ease of use and can be used more appropriately in an
asthma attack. Chitosan selected because it is a versatile and widely used
biopolymer for controlled drug delivery system for conveying formoterol, which is a
potent bronchodilator, by producing a film for sublingual deposition. And the
results obtained from the characterization showed membranes crystallinity
variations (XRD) according to the crosslinking process, besides presenting a
possible relationship between cross-linking and release. By FTIR one can observe
some interaction between the drug and amino groups of chitosan, and can
isomerization of drug by crosslinking with 5% TPP. Through optical and electronic
microscopy, it can be seen that addition of drug has provided some roughness to
the membrane. Also by microscopy verified the inhomogeneous crosslinking of the
membrane surface. EDS there was no foreign object the structure of chitosan and
the drug. By measuring the wetting angle can be checked increase the hydrophilic
profile of the membrane by addition of the drug, this profile has not been modified
by crosslinking process. The cytotoxicity assay results presented indicate that the
membrane as a promising candidate for in vivo testing.