Considerações hemato-bioquímicas de equinos da raça quarto de milha aclimatados em região tropical semiárida.

Abstract

The aim of this dissertation was to seek the laboratory profile in the area of hematology 10 and clinical biochemistry of horses acclimated in semi-arid tropical region. For this 11 purpose, it was divided into two chapters. Chapter I is an integrative systematic review 12 where we assess the potential for ESR sensitivity in the diagnosis of different 13 pathologies in horses. Therefore, a careful search was carried out in the Pubmed, 14 ScienceDirect, Scopus, Web of Science and SciELO databases by randomized clinical 15 studies until 2021, which culminated in the literary review of five studies. We 16 evidenced five horse breeds evaluated through ESR methodologies that varied between 17 the standard Westergren method or the modified Westergren method, with the use of 18 different anticoagulants, such as: ethylenediamine tetraacetic acid (EDTA), citrate and 19 heparin. ESR showed diagnostic sensitivity and positive correlation with 20 complementary laboratory parameters, such as: hemoglobin, plasma proteins, leukocyte 21 count and red blood cell count. It is also highlighted the need for studies with other 22 races and modulations of stress and pathological conditions, in particular that cover 23 other nationalities and the peculiarities in which they are inserted. While Chapter II 24 demonstrates the broad biochemical and hematological profile of healthy horses from 25 the tropical semiarid region of Brazil where it was performed on animals subjected to 26 intensive rearing with protein supplementation. For this, an assessment of hematological 27 parameters (blood count, fibrinogen and vhs) and biochemical tests of liver function 28 (Albumin, Aspartate Aminotransferase, Alanine Aminotransferase, Bilirubin, Alkaline 29 Phosphatase, Gamma Glutamyltransferase, total proteins, renal function (Urea, 30 creatinine) were carried out ), muscle function (creatine kinase, Lactate Dehydrogenase, 31 Aspartate Aminotransferase), glycemic and lipid profile (Glucose, Cholesterol, 32 Triglycerides) and electrolyte profile (sodium, potassium, calcium, magnesium, 33 chlorine). In all hematological and biochemical parameters analyzed, the results 34 obtained were within the established reference values, despite slight oscillations, as 35 expected for healthy horses inserted under semi-arid geoclimatic conditions. The values 36 obtained for the hematological and biochemical parameters evaluated can be used in the 37 interpretation of laboratory tests of inserted horses under conditions similar to the 38 present study. It is concluded that in healthy horses under tropical and semi-arid 39 geoclimatic conditions they presented hematological and biochemical parameters within 40 the normality values pre-established in the literature, with slight oscillations probably 41 due to adaptive physiological processes.