Risco de trombocitopenia induzida por fármacos: uma revisão integrativa da literatura.

Abstract

Thrombocytopenia was defined as a platelet count below 150,000/mm3, and when it is induced by drugs, it can be due to immune, non-immune causes and drug-dependent antibodies, causing serious problems for patients seeking to treat other diseases. This disorder can increase bleeding, making bleeding frequent and even causing thrombosis. The objective of this work was to carry out a survey of studies regarding thrombocytopenia induced by drugs and their drug classes. To this end, an integrative review was carried out in the databases: Scielo, Pubmed, Lilacs and Periódicos Capes, using a combination of keywords. 20,956 publications were identified in the databases, and after applying the inclusion and exclusion criteria, 536 articles remained for complete reading, resulting in 40 articles selected to compose the present study, these being from the period from 1971 to 2024. In the results, 13 were highlighted. medications from four distinct drug classes: anticonvulsants, antihypertensives, anticoagulants and hypoglycemics. Which demonstrated, according to the literature, a rare potential, but with enormous danger of inducing thrombocytopenia as an adverse effect. Therefore, it is of public benefit to highlight thrombocytopenia as a dangerous adverse effect, and which medications induce this blood dyscrasia, in addition to highlighting diagnosis and maintenance, helping health professionals with regard to monitoring the patient from the beginning of taking of the new drug, demonstrating that correct pharmaceutical assistance can save lives.