Estudo da toxicidade aguda do extrato da raiz de Keameria tomentosa A.St.Hil em camundongos e sua ação biológica em feridas cutâneas de ovinos (Ovis aries).

Abstract

This study aimed at evaluating the effects of topical treatment of ethanol extract of Krameria tomentosa root in skin wounds of sheep. Fourteen Santa Ines female sheep were numbered and divided into 4 groups according to the treatments. Animals numbered from 1 to 7 had control treatment on the left side. On the right side, the treatment was conducted with plant extract at 10%. Animals numbered from 8 to 14 were treated with ointment based on antibiotic on the left side. The plant extract at 5% was used on the right side for this group. The treatment was performed on wound everyday and the macroscopic and microscopic evaluations made conductedweekly. The wounds evaluations were performed through clinical, morphometric and histopathological points of views in pre-determined periods of time. Morphometrically, the wounds treated with the plant at 5% showed a higher percentage of contraction than in other groups in all evaluations. Histopathologically, the wounds of the treated groups showed better healing than the ones of the control group. The wounds of the group treated with the extract at 5% showed more total healing characteristics from the 21st day.