FEITOSA, Leonardo Falcão.; FEITOSA, Leonardo Falcão.
Résumé:
In conventional medical therapy the drug is administered via a dosage form and
produces a tissue level of the drug that is not maintained within the therapeutic range
over an extended period of time. Thus, the success of the treatment will depend on
several factors such as accurate and frequent dosing at predetermined specific times
and patient adherence to therapy so that the non-compliance to the treatment
regimen can result in use of the drug in not effective range or toxic levels Due to the
great problem of maintaining serum levels of drugs in the human body, especially in
the case if drugs related to the treatment of moderate to severe pain, this paper
proposes the development of porous membranes chitosan base, which is a
biocompatible natural polymer, capable of promoting the controlled release of
fentanyl. The matrices obtained were characterized by: OM, SEM, EDS, FTIR, XRD,
Swelling test, biodegradation test and Cytotoxicity Assay. For OM and SEM there
was apparently a surface with interconnected pores. From the EDS analysis can
verify the elements of chitosan and drug. FTIR and XRD noted not to change
functional groups of crystallinity and, respectively, of the material due to the
incorporation of the drug. Based on swellings and biodegradation tests verified the
ability to control the following variables: swelling ratio and degradation rate solely by
varying the concentration of the chitosan porous membrane. It was found that the
cytotoxicity assay the membranes, even with the incorporation of the drug did not
show cytotoxicity. Based on the results obtained it was concluded that it is possible to
synthesize a polymer matrix with promising properties to adduce drug and in vivo
tests.
