Anticonvulsant activity of thymoquinone and its structural analogues.

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dc.description.resumo	It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds.	pt_BR
dc.publisher.country	Brasil	pt_BR
dc.publisher.initials	UFCG	pt_BR
dc.subject.cnpq	Farmácia.	pt_BR
dc.subject.cnpq	Química.	pt_BR
dc.title	Anticonvulsant activity of thymoquinone and its structural analogues.	pt_BR
dc.date.issued	2011
dc.identifier.uri	http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227
dc.date.accessioned	2024-08-08T23:00:04Z
dc.date.available	2024-08-08
dc.date.available	2024-08-08T23:00:04Z
dc.type	Artigo de Periódico	pt_BR
dc.subject	Quinonas	pt_BR
dc.subject	Atividade anticonvulsivante	pt_BR
dc.subject	Seizures	pt_BR
dc.subject	Convulsões	pt_BR
dc.subject	Sistema nervoso central	pt_BR
dc.subject	Central nervous system	pt_BR
dc.subject	Structure-activity relationships	pt_BR
dc.subject	Oils	pt_BR
dc.subject	Óleos	pt_BR
dc.subject	Quinones	pt_BR
dc.subject	Anticonvulsant activity	pt_BR
dc.subject	Seizures	pt_BR
dc.subject	Convulsions	pt_BR
dc.subject	Central nervous system	pt_BR
dc.subject	Central nervous system	pt_BR
dc.subject	Structure-activity relationships	pt_BR
dc.subject	Oils	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.creator	SOUSA, Damião Pergentino de.
dc.creator	NÓBREGA, Franklin Ferreira de Farias.
dc.creator	SANTOS, Camila C. M. P.
dc.creator	BENEDITO, Rubens Batista.
dc.creator	VIEIRA, Ygor W.
dc.creator	ULIANA, Marciana Pierina
dc.creator	BROCKSON, Timothy John.
dc.creator	ALMEIDA, Reinaldo Nóbrega de.
dc.publisher	Universidade Federal de Campina Grande	pt_BR
dc.language	eng	pt_BR
dc.title.alternative	Atividade anticonvulsivante da timoquinona e seus análogos estruturais.	pt_BR
dc.identifier.citation	SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; SANTOS, Camila C. M. P.; BENEDITO, Rubens Batista; VIEIRA, Ygor W.; ULIANA, Marciana Pierina; BROCKSON, Timothy John; ALMEIDA, Reinaldo Nóbrega de. Anticonvulsant activity of thymoquinone and its structural analogues. Revista Brasileira de Farmacognosia, v. 21, p. 427-431, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227	pt_BR