Vitamina C no choque séptico: uma revisão sistemática.

Abstract

Septic shock is a serious condition that affects multiple organs, causing severe hypotension in patients, which results in high rates of hospital mortality, prolonged hospitalization, and elevated costs for the healthcare system. Septic patients have reduced levels of vitamin C, which can hinder the body's performance, as it is a cofactor for the synthesis of catecholamines and vasopressin, in addition to improving the response to a vasoconstrictor. The objective of this article is to determine whether bolus infusion of vitamin C in patients with septic shock increases survival. To this end, a systematic review was conducted according to PRISMA guidelines. From a structured and comprehensive search of electronic databases, six studies were included in the review. The inclusion criteria specified that only randomized studies were considered. The results found do not provide sufficient information to assert that there is an increase in survival following the use of vitamin C.