Atividade antifúngica de um o-glicosídeo 2,3-insaturado.

Abstract

Candida infections cause high rates of morbidity and mortality, especially by the increase of the microbial resistance, fact that makes difficult the treatment of the diverse forms of clinical manifestations presented by this microorganism. The limitations of conventional antifungal agents lead to research for new antifungal or combinations of antifungal substances. The objective of this study was to evaluate the antifungal action of a 2,3-unsaturated O-glycoside against Candida non-albicans and its combination with amphotericin B or ketoconazole. The antifungal activity test was performed by the broth microdilution method and the association with amphotericin B or ketoconazole by the checkerboard method. As a result it was observed that the compound was not able to inhibit fungal growth, but showed synergistic activity in association with amphotericin B and indifferent with ketoconazole. It concludes that an isolated use of the glycoside as an antifungal is not feasible, however its use in combination with amphotericin B may be a therapeutic alternative, and it is necessary to carry out in-depth studies on this combination.