TEIXEIRA, C. M. L. C.; http://lattes.cnpq.br/3656978567003311; TEIXEIRA, Cláudia Maria Lopes Carneiro.
Resumo:
The Dermatology searches biocompatible, safe and cost effective materials as
injectable soft-tissue augmentation fillers for facial loss treatments, also from HIV-related
facial lipoatrophy. This work proposes to formulate a 70% carboxymethylcellulose (CMC),
glycerin (GL) aqueous polysaccharide gel and 30% synthetic calcium hydroxylapatite (HAp)
approached to the standard commercial product, Radiesse®. The HAp was successful
synthesized by precipitation method, evaluated by X rays diffraction (DRX), after that,
calcined at 900°C and 1100°C, resulting in higher medium sizes chipboards. These had been
evaluated by DRX, spectroscopy for fluorescence of X rays (EDX), the Fourier transform
infrared spectroscopy (FTIR), grain sized distribution (DG) and scanning electron microscopy
(SEM). An aqueous polysaccharide composite gel was developed, added 30% of the
synthesized HAps, obtaining proposed experimental composites and evaluated by DRX,
EDX, FTIR and SEM. The commercial product cited was evaluated by the techniques of
characterizations listed and its results had proven that this material is composed by 30% stable
phase crystalline HAp involved in a 70% CMC, GL aqueous polysaccharide gel, with welldefined
visual viscosity and drying time at room temperature. The data of the commercial
product had been compared to the proposed experimental composites ones, including visual
viscosity and drying time measurements. The experimental composites had been gotten
successfully with or without heat treatment and had presented, among themselves, only
changes related to crystallite and droplet sizes demonstrated by SEM, and the drying time,
which could be improved and evaluated later in vitro and in vivo studies to verify their
biological behaviors.