Estudo da atividade antifúngica da associação de adutos de Morita-Baylis-Hillman com antifúnficos sintéticos contra espécies de candida spp.

Abstract

Candida fungi are opportunistic pathogens, commonly found in the normal human microbiota, and candidiasis is one of the most common opportunistic mycoses worldwide, mainly affecting immunocompromised individuals. The objective of the present study was to evaluate the antifungal activity of the Morita-Baylis-Hillman Adduct association with synthetic drugs on Candida species. The tests to determine the Minimum Inhibitory Concentration (MIC) were performed using the microdilution technique, and the association tests were performed using the checkboard technique. Morita-Baylis-Hillman adducts showed antifungal activity against strains of Candida albicans and absence of activity against strains of Candida non-albicans. In addition, the association of the Morita-Baylis-Hillman adduct with the synthetic antifungal caspofungin was synergistic, an important activity due to the search for new substances that would increase the options of pharmacotherapy, increasing the spectrum of action of antibiotics, while the association with amphotericin B was indifferent.