Efeito do consumo de nata caprina nos níveis de peroxidação lipídica cerebral e parâmetros comportamentais em ratos idosos.

Abstract

The elderly population is affected by several pathologies that are natural to the aging process, especially anxiety, cognitive impairment and depression. To prevent these changes it is essential to maintain a balanced and healthy diet. In this sense, the use of goat's milk has been increasing because it presents recognized benefits to human health. Thus, the objective of this work was to evaluate the effect of goat cream consumption on behavioral parameters in elderly rats. Thirteen male wistar rats, aged 18 months, were divided into two groups: CG (control group) receiving distilled water, with a total of n = 6 and CNG (caprine cream group) n = 7, which was supplemented with goat cream for 30 days. To evaluate the effect of supplementation on the anxiety behavior of the animals, the tests of open field, high cross labyrinth, light-dark box and oxidative stress were performed through the levels of cerebral malonaldehyde. The results were expressed as mean and standard error of the mean, considering the level of significance p <0.05. In the open field test, the GNC group presented greater ambulation than the CG group (p <0.05), and grooming and rearing behavior were significantly lower in the GNC group, compared to the CG group (p <0.05). In relation to the high cross maze test, CNG presented higher number of entries and length of stay in the open arms and in the central area, besides a larger number of head dips when compared to the control group (p <0.05). The time of stay in the closed arms was lower in the GNC in relation to the CG (p <0.05). The dark light box test did not present a significant difference between the groups (p> 0.0.5). The level of lipid peroxidation was lower in GNC compared to GC. Therefore, these results demonstrate that the consumption of goat cream promoted an anxiolytic effect and reduction of cerebral lipid peroxidation, indicating potential effect on the control of the oxidative stress inherent to aging, preventing the behavior of anxiety in elderly rats.