Influência dos ácidos hidroxicinâmicos na proliferação e ciclo celular do câncer de pulmão: uma revisão.

Abstract

Cancer is the name given to the set of diseases characterized by the uncontrolled proliferation of cells. Lung cancer is the number one in mortality in men and the second in women, and is associated with smoking and genetic factors. Most cases are diagnosed in advanced stages. Surgical intervention is the main therapy, followed by chemotherapy and radiotherapy protocols. Hydroxycinnamic acids, present in foods, are potent antioxidants, capable of positively influencing the inflammatory process of chronic diseases, such as cancer. This project aims to review the literature on the influence of HA on the proliferation and cell cycle of cancer, evidencing its properties in lung cancer. The study was carried out through internet access and in the library of the Federal University of Campina Grande, Campus de Cuité - PB (UFCG). The research was done in the databases Medline, Pubmed, Lilacs, Scielo, Google Academic and national and international health committees, with the following terms: hydroxycinnamic acids, lung cancer, antioxidant and antitumor activity. Publications of the last eight years have been used. he study showed that there is still no clarification on how HA should be used in the prevention and treatment of cancer and that there is a great field to be studied with regard to a better understanding of how HA regulates oxidative stress and how it can be applied, the amount to be ingested and that is absorbed, which target tissues and their mechanisms of action, these data are still scarce.