Arcabouços de quitosana: avaliação da influência da massa molar e do processo de congelamento na biodegradação.

Abstract

Research by scaffolds have intensified in recent years with the purpose of developing three-dimensional porous structures that control effectively the adhesion, migration, proliferation and differentiation. The properties in desired scaffolds depend directly and intimately on the properties scaffolds for having capacity of molding in various forms and their ability to form porous structures using techniques such as lyophilization. This study aimed to develop lyophilized chitosan scaffolds, using chitosan of low, medium and high molecular weight; under two freezing temperatures to -60 ° C and -150 0 C. The material was characterized by Differential Scanning Calorimetry (DSC), Spectroscopy in the Region of Fourier Transform Infrared (FTIR), and X-Ray Diffraction (XRD). Already the scaffolds were characterized by the techniques of Differential Scanning Calorimetry (DSC), Spectroscopy in the Region of Fourier Transform Infrared (FTIR), and X-Ray Diffraction (XRD), scanning electron microscopy (SEM), swelling degree, Essay mechanical (compression) and in Vitro testing of Biodegradation. In the results, we conclude that chitosan's of different molecular weights and temperatures result in scaffolds with different morphological properties