Estudo da solubilização de alguns anti-inflamatórios não-esteroides utilizando sistemas microemulsionados.

Abstract

Some nonsteroidal anti-inflammatory drug are classified as Class II drugs according to the biopharmaceutical classification system, having low solubility and high permeability. The low aqueous solubility of a drug / formulation can interfere with the absorption and hence the therapeutic effectiveness. This work has as main objective the study of microemulsion systems in non-steroidal anti-inflammatory solubilization analyzed as four pharmaceutical compositions commercially sold containing nimesulide, ibuprofen, diclofenac sodium and potassium diclofenac. This required the completion of a previous study of the behavior of microemulsion systems through the construction of pseudoternários diagrams. For the construction of the microemulsion diagrams we use the following constituents: Tween 20 as surfactant, Propylene glycol as cosurfactant, the Mineral Water for aqueous phase to oil phase we opted to choose substances from raw materials abundant in our region, northeast of Brazil. This study allowed us to choose the most appropriate Winsor region and through a method called Network Scheffé choose seven points for each diagram, with predetermined values microemulsions. Then, it was further given to solubility tests in microemulsion and in water, followed by the calculation process yield. The results obtained showed that the solubility in the microemulsion, the pharmaceutical compositions satisfactorily increased, reaching up to 10 times higher than the results obtained in water. Thus, the study and the results allowed us to observe the subject importance to the pharmaceutical field, especially for large industries producing medicaments, where the use of microemulsion systems appears as pharmaceutical technology option for remediation related to solubility problems.