Identificação e avaliação de potenciais interações medicamentosas em pacientes da unidade de terapia intensiva do Hospital Universitário Alcides Carneiro.

Abstract

on the effect of another medication, which has been previously or concurrently administered to the first, causing a pharmacological or clinical response. Combinations of drugs to treat chronic diseases are very common, especially in intensive care unit patients (ICU), however, can cause drug interactions, which are responsible for treatment failure, endangering the lives of patients and generating high costs for the hospital. This study aims to analyze the occurrence and the profile of potential drug interactions in the University Hospital Alcides Carneiro ICU patients. A descriptive research with quantitative and qualitative approach was carried out. Data collection was done between January to June 2015, from prescriptions ICU. Data were collected through a specific form for this purpose. For the identification of potential interactions utilized the Drug-Reax Software System Micromedex® Health Series. Among the 109 prescriptions evaluated, 76 (69.72%) had some interaction, totaling 244 potential interactions. The profile of most interactions found was: pharmacodynamic mechanism of action, greater degree of severity, reasonable documentation and onset of action not specified. There was an average of 6.91 medications per prescription. All patients who received 10 or more drugs had some interaction. The polypharmacy can be considered a risk factor for the occurrence of interactions. The results show that the emergence of interactions in the ICU has a high prevalence. The use of associations that can cause drug interactions is justified by their risk / benefit, which should be evaluated by the pharmacist and the healthcare team. To reduce the appearance of possible interactions is essential to monitor the prescriptions and it is necessary that health professionals have knowledge about the mechanisms of action of potential interactions so that there is continuous monitoring and observance of patients, thereby improving the clinical management and avoiding complications that may occur.