Controle de qualidade e avaliação da atividade antimicrobiana de gargarejo produzido pelo CENEP de Nova Palmeira-PB.

Abstract

The pharyngotonsilitis is an acute inflammatory disease that affects the oropharynx and tonsil simultaneously. About 15 to 30% of cases the disease is of bacterial origin, and Streptococcus pyogenes, agent envolved. Many plants of Brazilian biomes, have been used by local people for treating various tropical diseases, fungal and bacterial infections. In Popular Education Center (CENEP), non-governmental organization located in New Palm-PB, are used several native plants present in caatinga biome, where besides the natural remedies are also complementary therapies offered. However, like any medicament, those based on plants should prove its efficacy and safety for use, requiring quality control procedures are established throughout the production chain. Thus, the study aimed to carry out the assessment of quality parameters and in vitro antimicrobial activity of gargle produced by CENEP, and phytochemical and ethnobotany research of the plants that compose it. Was performed on three samples gargling, the count of viable microorganisms and pathogen specific search based on limits set by the pharmacopoeia, and determination of physico-chemical parameters such as pH, viscosity, density, dry and organoleptically. It was also carried out to prove the antimicrobial efficacy against S. pyogenes using the agar diffusion method and phytochemical description. Because it is a product of natural origin, or gargle within the limits established by the Brazilian Pharmacopoeia. The gargle, after measuring the diameters of the inhibition halos, presented antimicrobial activity against S. pyogenes considerable. Samples showed fungal contamination by Cladosporium spp. The physical and chemical parameters, the phytochemical and ethnobotanical research, corroborated with data in the literature. Overall, gargling is presented, at the end of the study, suitable for marketing, in view of the proof of therapeutic effect and absence of pathogens that could interfere in the formulation and cause harm to the user.