LEAL, R. C. A.; http://lattes.cnpq.br/3883482564897016; LEAL, Rita de Cássia Alves.
Abstract:
The hydroxyapatite is one of the most biocompatible materials known by
encouraging bone growth. However, the main drawback it is the poor
mechanical strength. A method to overcome this problem is the addition of the
biopolymer chitosan, suitable for applications as biomaterials. In this study was
obtained a hydroxyapatite - chitosan biocomposites for application as a
biomaterial. To obtain the biocompositos, hydroxyapatite granules were added
under constant stirring in a solution of chitosan in quantities necessary to obtain
a product with a ratio 70:30 (HA/CS). Then the paste formed was filtered and
pressed to obtain the biocomposite disk. The analysis of scanning electron
microscopy (SEM) of the biocomposite HA/CS, indicated that there was a good
dispersion of particles of HA chitosan in the presence of small pores on the
surface of the sample. XRD results showed no significant change in the profile
of hydroxyapatite (HA) with the incorporation of chitosan. It was observed in the
analysis by Infrared Spectroscopy with Fourier Transform (FTIR) bands
characteristic of hydroxyapatite, as well as bands that characterize the
interaction between chitosan and hydroxyapatite. According with the analysis of
water absorption the biocomposites HA/CS showed water absorption of
approximately 48.365%. The biocompatibility of biocomposites HA/CS was
confirmed with the MTT assay, where did not reveal a toxicity of same.
The biocomposites presented mechanical strength values lower than
those reported in literature for use in cortical bone, the mechanical
strength obtained at different processing conditions allow its use in spongy
bone replacement. According with results, we can concluded that the obtained
had biocomposites, the morphological point of view, features dense showed
no toxicity, they maintained their crystallographic features demonstrated
interactions between the compounds and had mechanical properties which
fall between the values reported for compact and spongy bone, which allows
an application to replacement of spongy bone.