Uso anti-inflatórios não esteroidais e Doença Renal Crônica: revisão integrativa.

Abstract

Chronic Kidney Disease (CKD) is a public health problem in several countries and it depicts one of the main causes of morbidity and mortality in the world. Another problem of public relevance is the indiscriminate use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), particularly by the elderly population, to relief pain and inflammation. This paper objectifies elucidating the relation between the use of NSAIDs and its repercussion in CKD patients. In regards of the methodological design, it was made an integrative bibliographic review. As research source, it was used the following data banks: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO) and Medical Published – service of the U.S National Library of Medicine (PubMed). It was selected, for analysis, only articles published in the last ten years. The majority of them have demonstrated that NSAIDs can lead to CKD progression, depending of some variables, like the exposition time to the medication, the specific kind of NSAID utilized and the CKD stage in which the patient is. Given to the critical analysis of the found results, it is possible to conclude that it is needed health education on the indiscriminate use of these medications and, when necessary, they should be prescribed in the lowest effective dose, monitoring renal function.