SOUZA, Navarro Nunes de.
Résumé:
Tablets are the most widely used pharmaceutical form in the world, due to its many
advantages offered to both the industry and the patient. Its manufacturing is an industrial
process composed of several stages, most of them requiring the use of robust equipment,
making this practice difficult to simulate in the classroom environment. Therefore the aim of
this work is the development of AAS tablets, using a small scale compression methodology
for practical classes of solid dosage forms, with the purpose of demonstrating the manufacture
of tablets in all its stages, from the synthesis to the quality assays, unifying theoretical
knowledge of the various disciplines involved in this production process as experimental
organic chemistry with the synthesis of the active principle, the pharmacotechnics with the
study of the excipients and formulation, and the discipline of quality control of drugs with the
post-manufacture tests. The following tests were performed: Appearance, average weight,
hardness and friability. The batch presented acceptable appearance being this white color,
circular and flat forms free of foreign material. The mean weight was 2,467 g, within the
acceptable range, being this result less than 5% as recommended in pharmacopoeia. None of
the tablets tested had a hardness higher than 30 Newton recommended in pharmacopoeia,
demonstrating that the process did not present adequate compression. As for friability, the
tablets presented a loss of 23% of mass after the test, being this value superior to 1.5%
recommended in pharmacopoeia. However, the practice of making the tablets has brought to
the student more proximity to such an industrial process, and with that, materializing his
multidisciplinary theoretical knowledge, resulting in the formation of a professional more
prepared for the job market.
