Obtenção de micropartículas de quitosana pela técnica de reticulação polimérica interfacial usando trimetafosfato de sódio.

Abstract

Chitosan is a natural biopolymer derived from the alkaline deacetylation of chitin, a polymer extracted from the exoskeleton of crustaceans such as crab and shrimp, chitosan has been used as a matrix of microparticles and crosslinked systems for immobilization and drug release conferring stability, safety and efficacy, in that case, microencapsulation is defined as the coating technology of active products, these products are encapsulated in polymer layers which can release the material under specific conditions and, at controlled rates of speed and quantity, by the development of microspheres or microcapsules. The advantages of this biopolymer in relation to the other polysaccharides, it‟s about their non-toxicity and biodegradability, beyond being a product of easy obtaining and a low cost. The present work had like objective of producing microparticles of chitosan by the interfacial polymeric crosslinking method us ing sodium trimetaphosphate as a crosslinking agent. It was also a preformulation study, constituting different concentrations of polymer, crosslinking agent and two agitation, everything to better evaluate if it has direct relation with the size of the microparticles. From this method microparticles were produced which maintained the spherical shape and a wrinkled surface appearance varying in size only according to the formulation, it was seen that parameters such as concentration of the crosslinking agent and speed of agitation, influenced the size of the microparticles. Concluding that with the interfacial polymeric crosslinking, through the use of sodium trimetaphosphate it is possible to obtain chitosan microparticles.