Avaliação da eficácia conservante em gel de babosa para a Farmácia Escola Manoel Casado de Almeida.

Abstract

Microbial contamination of pharmaceuticals, cosmetics and herbal products can be of various origins, so it has now been treated in a more careful scientific way, due to concerns regarding not only the microbiological aspects, but also the potential for irritation and toxicity. The microbiological quality of products is one of the essential attributes for their adequate performance, especially in relation to safety, efficacy and acceptability. Gels are semisolid systems which consist of dispersions of small or large molecules in liquid carrier which represent a medium conducive to the growth of microorganisms, as a consequence of which the inclusion of preservatives in the formulation is an essential factor to guarantee the quality and the microbiological stability of the preparations, preventing microbial proliferation. Thus, the objective of this work was to perform the efficacy test of the preservative system used in the slug gel manipulated at the Manuel Casado de Almeida School Pharmacy, belonging to the Education and Health Center of the UFCG, located in the municipality of Cuité-PB. The challenge test was performed, which consists of the deliberate contamination of finished products with standardized inoculums of each of the micro-organisms: Staphylococcus aureus; Pseudomonas aeruginosa; Escherichia coli; Candida albicans and Aspergillus niger, followed by determination of the number of viable microorganisms by the pour plate method in the times 0, 14 and 28 in formulations with and without preservative. In view of the criteria recommended by the Brazilian Pharmacopoeia V the results obtained showed that the preservative system was effective only against the microorganisms C. albicans and A. niger. Thus, new studies are suggested for the best combination preservatives and their optimal concentration.