OLIVEIRA, W. C.; http://lattes.cnpq.br/6571161647626024; OLIVEIRA, Waldinéa Cosme de.
Resumen:
Microbial contamination of pharmaceuticals, cosmetics and herbal products can be of various
origins, so it has now been treated in a more careful scientific way, due to concerns regarding
not only the microbiological aspects, but also the potential for irritation and toxicity. The
microbiological quality of products is one of the essential attributes for their adequate
performance, especially in relation to safety, efficacy and acceptability. Gels are semisolid
systems which consist of dispersions of small or large molecules in liquid carrier which
represent a medium conducive to the growth of microorganisms, as a consequence of which
the inclusion of preservatives in the formulation is an essential factor to guarantee the quality
and the microbiological stability of the preparations, preventing microbial proliferation. Thus,
the objective of this work was to perform the efficacy test of the preservative system used in
the slug gel manipulated at the Manuel Casado de Almeida School Pharmacy, belonging to
the Education and Health Center of the UFCG, located in the municipality of Cuité-PB. The
challenge test was performed, which consists of the deliberate contamination of finished
products with standardized inoculums of each of the micro-organisms: Staphylococcus
aureus; Pseudomonas aeruginosa; Escherichia coli; Candida albicans and Aspergillus niger,
followed by determination of the number of viable microorganisms by the pour plate method
in the times 0, 14 and 28 in formulations with and without preservative. In view of the criteria
recommended by the Brazilian Pharmacopoeia V the results obtained showed that the
preservative system was effective only against the microorganisms C. albicans and A. niger.
Thus, new studies are suggested for the best combination preservatives and their optimal
concentration.