Análise da qualidade de cápsulas de cloridrato de metformina 500 mg produzidas em farmácias magistrais no sertão da Paraíba.

Abstract

Diabetes mellitus (DM) comprises a metabolic syndrome characterized by increased blood glucose levels caused by insulin resistance or a deficiency in its secretion. Such disease can be classified into two types: type I (DM1) and type II (DM2) and gestational. Among the drugs used for the treatment of DM 2, metformin (marketed as metformin hydrochloride) stands out, which has low side effects and low risk, as well as proven good efficacy when compared to other antidiabetic drugs used for the treatment of DM 2. treatment. The objective of this study was to evaluate the physicochemical quality of 500 mg metformin hydrochloride master capsules from five pharmacies with manipulation in the cities of Paraíba: Catolé do Rocha, Pombal, Patos and Sousa, through tests recommended by the Pharmacopoeia. Brazilian 5th edition. Thus, with the accomplishment of the present work it was possible to observe that all samples, except pharmacy B, passed the medium weight tests, however, in relation to the dosing and dissolution, they all failed, with content values ranging from 33% with a variation coefficient (VC) of 101.4% in sample B and 84% with VC = 6.10% in sample E and dissolution values between 30.12% ± 3.9 and 90.09% ± 36.02 for samples C and B, respectively. Despite passing the disintegration and average weight tests, this did not guarantee that the capsules had uniform content and were unsuitable for treatment.