ARAUJO, C. A.; http://lattes.cnpq.br/2872171595857690; ARAÚJO, Carlos de Alencar.
Resumen:
Diabetes mellitus (DM) comprises a metabolic syndrome characterized by increased blood
glucose levels caused by insulin resistance or a deficiency in its secretion. Such disease can be
classified into two types: type I (DM1) and type II (DM2) and gestational. Among the drugs
used for the treatment of DM 2, metformin (marketed as metformin hydrochloride) stands out,
which has low side effects and low risk, as well as proven good efficacy when compared to
other antidiabetic drugs used for the treatment of DM 2. treatment. The objective of this study
was to evaluate the physicochemical quality of 500 mg metformin hydrochloride master
capsules from five pharmacies with manipulation in the cities of Paraíba: Catolé do Rocha,
Pombal, Patos and Sousa, through tests recommended by the Pharmacopoeia. Brazilian 5th
edition. Thus, with the accomplishment of the present work it was possible to observe that all
samples, except pharmacy B, passed the medium weight tests, however, in relation to the dosing
and dissolution, they all failed, with content values ranging from 33% with a variation
coefficient (VC) of 101.4% in sample B and 84% with VC = 6.10% in sample E and dissolution
values between 30.12% ± 3.9 and 90.09% ± 36.02 for samples C and B, respectively. Despite
passing the disintegration and average weight tests, this did not guarantee that the capsules had
uniform content and were unsuitable for treatment.