Análise das ocorrências de eventos adversos pós-vacinal da vacina contra o Papiloma Vírus Humano.

Abstract

Vaccines are part of Brazil's history in many contexts. They arose from the need of the population affected by certain diseases, which for many years caused high mortality rates and were inserted in an impetuous environment. At the current juncture, vaccination is recognized as a preventive intervention that impacts on the reduction of morbidity and mortality resulting from immunopreventable diseases. In the face of new discoveries and analyzes related to the Human Papilloma Virus still in the ascendancy, which, although delineated for more than five decades, appears to us as little reflected and discussed by the population, we organized this foundation in order to clarify punctually the contexts most evaluated and that must be taken into account by both the academic population and society as a whole. The association of the HPV virus with cervical cancer began in 1949, when pathologist George Papanicolaou introduced the examination that through the technique of smearing material collected from the vaginal mucosa can identify the presence of abnormal cells of the medium. This was an epidemiological, analytical study with a quantitative approach. It sought to evaluate the occurrence of post-vaccination adverse events against HPV according to the parameters established by the PNI and the variables included in the Post Vaccination Adverse Event Notification / Investigation Card, version August 2014, as well as the severity of these effects. It is noteworthy that for the accomplishment of this study, all the requirements contained in Resolution 466/12 of the National Health Council were met, which provides for research involving human subjects, including prior approval by the Research Ethics Committee of the Federal University of Campina Grande . The collected data were tabulated and analyzed in the software Statistical Package for Social Sciences (SPSS), version 24.0 and the descriptive statistics of frequencies, besides the analysis of correlations between the parameters presented in the form of tables. Pain at the site after vaccine application was the most prevalent adverse reaction, followed by swelling at the site. Most of the interviewees did not present systemic manifestations and other types of manifestations and when they presented, the most prevalent were headache, drowsiness and muscular pain. Statistically significant correlations were found indicating that muscular pain and headache were the most enduring events, as well as the predominance of interviewees of the black race in reports of neurological manifestations and the lower presence of these adolescents in reports of headache and muscular pain, as well as a relationship between participants who reported drowsiness with the presence of diabetes and heart disease in the family. Subsequent investigations need to be conducted to elucidate the nature of these relationships found in this research.