Avaliação bioquímica de indivíduos expostos a alta concentração de flúor.

Abstract

The skeletal fluorosis is a chronic metabolic disorder caused by intake of high fluoride concentrations for extended periods of time. It is difficult to diagnose, and can lead to disability. The aim of this study was to analyze biochemical parameters associated with skeletal fluorosis in blood and urine of individuals exposed to high doses of fluoride in an endemic region of Hinterland Paraibano. This is an epidemiologic, observational, descriptive and cross based on quantitative data, statistical and comparative, descriptive analysis procedurc. The consisted of 25 participants divided into two groups: G1 individuals with FO (# 14) and exposed to fluoride and G2 individuals do not carry FO (# 11) and exposed to fluoride (4.46 mg / L in water). After the selection of volunteers was carried out by home visit to apply a tool to characterize the subjects. For biochemical analysis through the blood and urine of volunteers exposed to high concentration they were considered: type of container, volume, sample age, drugs and chemical compounds that could interfere with the examination. The results show that 72% are female, with the predominant age group of 61 years or more (29%), verifying that mostly consists of older persons, the residence time in the community and therefore exposure fluoride around 40 to 49 years (26%). The statistical analysis of biochemical parameters, the study shows that the average values of serum and hormone results obtained for G1 and G2, showed no significant differences in the measurements of biochemical tests between the groups, according to the Mann-Whitney test with p <0,05 established. However, the analysis of fluoride in urine, G1 and G2 groups showed changes in all samples, and this biomarker representing greater expression to fluoride exposure. We conclude that although some parameters show change in their levels, we can not infer that they can be directly related to this condition, in this location, given that age, nutrition, absence of harmful habits, medication and physical exercise in addition to other variables must be considered when analyzing this morbidity. Studies on the effects of chronic fluorosis through biochemical parameters in humans in endemic fluorosis area, still constitutes something incipient