COSTA, Jesyka Tais Medeiros Lins.
Resumo:
Solubility is the word that defines our research. Ampicillin is a drug currently used to treat infections as a powerful antibiotic. This medicament is administered as a suspension, which is causing serious problems dosage, displayed poor solubility in aqueous media. Importantly also, this medicine when absorbed in suspension, the user is likely to absorb in the upper and / or lower concentrations. Aiming to promote increased drug solubility this work has made several steps. Initially, we conducted solubility tests and studies to choice of trainers components of solubilizing agents. This need arose in order to promote the dispersion of ampicillin in liquid medium, motivating us to research methods favorable solubility. Our aim was to promote the solubilization and then suggest a new form of drug presentation in the pharmaceutical industry. For this reason, this study drug dispersion tests were performed in various solvents, and sequencing study of microemulsion systems using soybean oil (oil phase), propylene glycol 400 (surfactant) and water (Aqueous phase). The microemulsion diagrams were obtained using a titration to provide various points in the Winsor IV region. The choices of the points were based on an experimental methodology, following the order of an equilateral triangle, based on a method called Scheffé network, which were chosen nine points. These points were used in the solubility tests. The results obtained showed that the solubility of the drug reached 85%, the four point, which provides 4.5 grams of surfactant, 1.5 grams of oily phase and aqueous phase 4 grams of showing its efficacy.
